Maltodextrin-Conjugated Gd-Based MRI Contrast Agents for Specific Diagnosis of Bacterial Infections,ACS Applied Bio Materials

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Maltodextrin-Conjugated Gd-Based MRI Contrast Agents for Specific Diagnosis of Bacterial Infections
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-11-24 , DOI: 10.1021/acsabm.0c01246
Chen Xu _{1,

2,

3} , Zihou Li ₁ , Ozioma Udochukwu Akakuru ₁ , Chunshu Pan _{2,

3} , Ruifen Zou ₁ , Jianjun Zheng ₂ , Aiguo Wu ₁

Affiliation

Bacterial infections are one of the most serious health risks worldwide, and their rapid diagnosis remains a major challenge in clinic. To enhance the relaxivity and bacterial specificity of magnetic resonance imaging (MRI) contrast agents, here, a kind of gadolinium-based nanoparticles (NPs) of impressive biocompatibility is constructed as a contrast agent for maltodextrin-mediated bacteria-targeted diagnosis. To realize this, positively charged ultrasmall gadolinium oxide (Gd₂O₃, 2–3 nm) NPs are embedded in mesoporous silica NPs (MSN) with pore size around 6.38 nm. The resulting Gd₂O₃@MSN exhibits enhanced r₁ value and T₁-weighted MRI performance. Interestingly, upon conjugation of Gd₂O₃@MSN with maltodextrin to produce Gd₂O₃@MSN-Malt NPs, a remarkable decrease in internalization by osteosarcoma cells, alongside an increased adsorption toward E. coli and S. aureus, is achieved. It is therefore conceivable that the bacteria-targeted Gd₂O₃@MSN-Malt might be a promising MRI contrast agent for effective discrimination of bacterial infections from tumor.

中文翻译：

麦芽糊精结合钆基 MRI 造影剂用于细菌感染的特异性诊断

细菌感染是全球最严重的健康风险之一，其快速诊断仍然是临床的主要挑战。为了增强磁共振成像 (MRI) 造影剂的弛豫性和细菌特异性，本文构建了一种具有令人印象深刻的生物相容性的钆基纳米粒子 (NPs) 作为麦芽糊精介导的细菌靶向诊断的造影剂。为了实现这一点，带正电的超小氧化钆（Gd ₂ O ₃，2-3 nm）纳米颗粒嵌入介孔二氧化硅纳米颗粒（MSN）中，孔径约为6.38 nm。得到的 Gd ₂ O ₃ @MSN 表现出增强的r ₁值和T ₁加权 MRI 表现。有趣的是，在 Gd ₂ O ₃ @MSN 与麦芽糖糊精结合以产生 Gd ₂ O ₃ @MSN-Malt NPs 后，骨肉瘤细胞的内化显着降低，同时对大肠杆菌和金黄色葡萄球菌的吸附增加。因此可以想象，细菌靶向的 Gd ₂ O ₃ @MSN-Malt 可能是一种很有前途的 MRI 造影剂，可有效区分细菌感染和肿瘤。

更新日期：2020-11-24

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