Abstract

In the current research, two new Cu(II)-containing coordination polymers with the chemical formulae of [Cu₂(L)₂]·2DMA·3H₂O (1) and [Cu₂(L)₂]·H₂O (2, H₂L = 2-(imidazol-1-yl)terephthalic acid) have been solvothermally synthesized by reaction of Cu(NO₃)₂·3H₂O with the H₂L ligand in different solvent systems (DMA/H₂O for 1 and NMP/H₂O for 2), which have been well characterized by elemental analysis and the single crystal X-ray diffraction. Furthermore, their inhibitory effect against Staphylococcus aureus biofilms formation during spine surgery incision infection was evaluated and the detail mechanism was explored. The CFU numbers in the infectious site was counted after compound 1 or 2 treatment. And the real time RT-PCR was performed on Staphylococcus aureus biofilms genes expression after compounds treatment.

摘要

在目前的研究中，两种新的含Cu(II)配位聚合物的化学式分别为[Cu ₂ (L) ₂ ]·2DMA·3H ₂ O ( 1 ) 和[Cu ₂ (L) ₂ ]·H ₂ O ( 2 , H ₂ L = 2-(imidazol-1-yl)terphthalic acid) 已通过 Cu(NO ₃ ) ₂ ·3H ₂ O 与 H ₂ L 配体在不同溶剂体系 (DMA/H ₂ O 1和 NMP/H ₂ O 2)，已通过元素分析和单晶 X 射线衍射进行了很好的表征。此外，评估了它们对脊柱手术切口感染过程中金黄色葡萄球菌生物膜形成的抑制作用，并探讨了详细机制。在化合物1或2处理后计算感染部位的 CFU 数。并对化合物处理后的金黄色葡萄球菌生物膜基因表达进行实时RT-PCR 。