Abstract

In a group of 208 patients with chronic ischaemic heart disease, the variation of A₂-associated-LDL phosphatase (Lp-PLA₂) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA₂ can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy.

中文翻译：

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脂蛋白相关的磷脂酶A2（Lp-PLA2）–慢性缺血性心脏病的可能诊断和危险生物标志物

摘要

在一组208例慢性缺血性心脏病患者中，每两周进行一次动力学分析，以分析A ₂相关LDL磷酸酶（Lp-PLA ₂）血清浓度值的变化。该研究的结论是，血清Lp-PLA _2的值可以作为对慢性缺血性心脏病具有诊断特异性的生物标记物，这是一种在医学实践中真正有用的参数，无论是在患者还是临床上报告心绞痛的存在，未显示心电图有特定变化，并用于评估对个性化治疗的反应。