ABSTRACT

Introduction: Oral administration of a drug is the most common, ideal and preferred route of administration. The main problem of oral drug formulations is their low bioavailability arises from poor aqueous solubility of drug. Aqueous solubility of lipophilic drugs can be improved by various techniques like salt formation, complexation, addition of co-solvent etc. but self-emulsifying drug-delivery system (SEDDS) is getting more attention for increasing the solubility of such drugs. The SEDDS is an isotropic mixture of drug, lipids, and emulsifiers, usually with one or more hydrophilic co-solvents/co-emulsifiers. This system is having ability to generate oil-in-water (o/w) emulsions or microemulsions upon gentle agitation followed by dilution with aqueous phase. The SEDDSs are relatively newer, lipid-based technological innovations possessing unparalleled potential in improving oral bioavailability of poorly water-soluble drugs.

Areas covered: This review provides updated information regarding the types of SEDDS, their preparation techniques, drug delivery and related recent patents along with marketed formulations.

Expert opinion: The SEDDS has been explored for improving bioavailability, rising intra-subject heterogeneity, and increasing solubility. SEDDS offers the benefit of a protective effect against the hostile environment in the gut. The unique fabrication techniques provide specific strategy to overcome the low bioavailability and poor solubility problems.

摘要

介绍：口服药物是最常见，理想和首选的给药途径。口服药物制剂的主要问题是它们的低生物利用度是由于药物的水溶性差引起的。亲脂性药物的水溶性可以通过各种技术来改善，例如成盐，络合，添加助溶剂等，但是自乳化药物递送系统（SEDDS）在增加此类药物的溶解性方面受到越来越多的关注。SEDDS是药物，脂质和乳化剂的各向同性混合物，通常与一种或多种亲水性助溶剂/助乳化剂混合。该系统具有在温和搅拌，然后用水相稀释后产生水包油（o / w）乳液或微乳液的能力。SEDDS相对较新，

涵盖领域：这篇综述提供了有关SEDDS类型，其制备技术，药物输送和相关近期专利以及上市制剂的最新信息。

专家意见：SEDDS已被研究用于改善生物利用度，增加受试者体内异质性和增加溶解度。SEDDS具有抵御肠道有害环境的保护作用。独特的制造技术可提供特定的策略来克服生物利用度低和溶解性差的问题。