A population of CD4hiCD38hi T cells correlates with disease severity in patients with acute malaria,Clinical & Translational Immunology

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A population of CD4hiCD38hi T cells correlates with disease severity in patients with acute malaria
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-11-24 , DOI: 10.1002/cti2.1209
Simon H Apte _{1,

2} , Gabriela Minigo _{3,

4} , Penny L Groves ₁ , Jessie C Spargo _{3,

4} , Magdalena Plebanski _{5,

6} , Mathew J Grigg _{3,

4} , Enny Kenangalem ₇ , Julie G Burel _{1,

8} , Jessica R Loughland _{1,

3,

4} , Katie L Flanagan _{5,

6,

9} , Kim A Piera _{3,

4} , Timothy William ₉ , Ric N Price _{3,

10,

11} , Tonia Woodberry _{3,

4} , Bridget E Barber _{1,

3,

4} , Nicholas M Anstey ₃ , Denise L Doolan _{1,

12}

Affiliation

Infectious Diseases Program QIMR Berghofer Medical Research Institute Brisbane QLD Australia.
Present address: Queensland Lung Transplant Service, The Prince Charles Hospital Chermside QLD Australia.
Global and Tropical Health Division Menzies School of Health Research Casuarina NT Australia.
Charles Darwin University Darwin NT Australia.
Department of Immunology and Pathology Monash University Prahran VIC Australia.
School of Health and Biomedical Sciences RMIT University Bundoora VIC Australia.
Papuan Health and Community Development Foundation Timika Indonesia.
Present address: La Jolla Institute for Immunology La Jolla CA USA.
School of Medicine University of Tasmania Launceston TAS Australia.
Nuffield Department of Clinical Medicine Centre for Tropical Medicine and Global Health University of Oxford Oxford UK.
Mahidol-Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University Bangkok Thailand.
Centre for Molecular Therapeutics Australian Institute of Tropical Health & Medicine James Cook University Cairns QLD Australia.

CD4⁺ T cells are critical mediators of immunity to Plasmodium spp. infection, but their characteristics during malarial episodes and immunopathology in naturally infected adults are poorly defined. Flow cytometric analysis of PBMCs from patients with either P. falciparum or P. knowlesi malaria revealed a pronounced population of CD4⁺ T cells co‐expressing very high levels of CD4 and CD38 we have termed CD4^hiCD38^hi T cells. We set out to gain insight into the function of these novel cells.

中文翻译：

CD4hiCD38hi T 细胞群与急性疟疾患者的疾病严重程度相关

CD4 ⁺ T 细胞是疟原虫免疫的关键介质。感染，但它们在疟疾发作期间的特征和自然感染成人的免疫病理学尚不清楚。对恶性疟原虫或诺氏疟原虫疟疾患者的 PBMC 进行流式细胞术分析显示，大量 CD4 ⁺ T 细胞共表达非常高水平的 CD4 和 CD38，我们将其称为 CD4 ^hi CD38 ^hi T 细胞。我们着手深入了解这些新型细胞的功能。

更新日期：2020-11-25

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