Immunoglobulin A vasculitis/Henoch–Schönlein purpura (IgAV/HSP) is a major cause of vasculitis in children. It is often accompanied by nephritis (HSPN) and could progress to chronic kidney disease. Galactose‐deficient IgA₁ was recently reported to be involved in the pathogenesis of HSPN, for which immunosuppressive drugs are considered key treatment. However, the involvement of immune cells in the development of HSPN remains unclear.

中文翻译：

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活化的细胞毒性 T 淋巴细胞和自然杀伤细胞在 Henoch-Schönlein 紫癜性肾炎中的作用

免疫球蛋白 A 血管炎/过敏性紫癜 (IgAV/HSP) 是儿童血管炎的主要原因。它通常伴有肾炎 (HSPN)，并可能发展为慢性肾病。最近有报道称，半乳糖缺乏的 IgA ₁参与了 HSPN 的发病机制，而免疫抑制药物被认为是关键的治疗方法。然而，免疫细胞参与 HSPN 的发展仍不清楚。