The ability to quantify drugs and metabolites in tissue with sub‐mm resolution is a challenging but much needed capability in pharmaceutical research. To fill this void, a novel surface sampling approach combining laser ablation with the commercial dropletProbe automated liquid surface sampling system (LA‐dropletProbe) was developed and is presented here.

中文翻译：

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使用激光消融-液滴探针-质谱法对小鼠大脑和肝脏薄组织 200 μm 区域中的心得安进行绝对定量

以亚毫米分辨率量化组织中的药物和代谢物的能力是药物研究中一项具有挑战性但急需的能力。为了填补这一空白，开发了一种将激光烧蚀与商用 dropletProbe 自动液体表面采样系统 (LA-dropletProbe) 相结合的新型表面采样方法，并在此进行了介绍。