Cover Feature: Single‐Step Glycosylations with 13C‐Labelled Sulfoxide Donors: A Low‐Temperature NMR Cartography of the Distinguishing Mechanistic Intermediates (Chem. Eur. J. 6/2021),Chemistry - A European Journal

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Cover Feature: Single‐Step Glycosylations with 13C‐Labelled Sulfoxide Donors: A Low‐Temperature NMR Cartography of the Distinguishing Mechanistic Intermediates (Chem. Eur. J. 6/2021)
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2020-11-24 , DOI: 10.1002/chem.202004805
Andrés G. Santana ₁ , Laura Montalvillo‐Jiménez ₁ , Laura Díaz‐Casado ₁ , Enrique Mann ₁ , Jesús Jiménez‐Barbero _{2,

3} , Ana M. Gómez ₄ , Juan Luis Asensio ₁

Affiliation

The mechanistic study of one‐step sulfoxide glycosylations enabled by the employment of ¹³C‐labelled glycosyl‐donors and low‐temperature NMR revealed the internal dynamics between all reaction intermediates involved in this process, which are represented in the accompanying image as a molecular rollercoaster. The formation and stability of donor/acceptor sulfonium adducts, inherent to this particular experimental protocol, defines the scope of this synthetic methodology. More information can be found in the Full Paper by A. G. Santana, J. L. Asensio, et al. on page 2030.

中文翻译：

封面人物：具有13C缩合亚砜供体的单步糖基化：区分机制中间体的低温NMR谱图（Chem。Eur。J. 6/2021）

通过使用^13个C标记的糖基供体和低温NMR进行的一步式亚砜糖基化机理的研究揭示了该过程涉及的所有反应中间体之间的内部动力学，在所附图像中以分子过山车形式表示。该特定实验方案固有的供体/受体sulf加合物的形成和稳定性定义了该合成方法的范围。可以在A. G. Santana，J。L. Asensio等人的《全文》中找到更多信息。在2030页。

更新日期：2021-01-27

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