Rhodium(III)‐Catalyzed Alkylation of 2‐Arylquinazolin‐4(3H)‐ones with Cyclopropanols by Directing C‐H Activation and Ring Opening at Ambient Temperature,Asian Journal of Organic Chemistry

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Rhodium(III)‐Catalyzed Alkylation of 2‐Arylquinazolin‐4(3H)‐ones with Cyclopropanols by Directing C‐H Activation and Ring Opening at Ambient Temperature
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-11-24 , DOI: 10.1002/ajoc.202000459
Mu‐Wang Chen ₁ , Minhao Lou ₁ , Zhihong Deng ₁ , Qin Yang ₁ , Yiyuan Peng ₁

Affiliation

An efficient method was developed for the alkylation of 2‐arylquinazolin‐4(3H)‐ones with cyclopropanols. The desired products β‐aryl ketones bearing the quinazolin‐4(3H)‐one scaffold were synthesized by Rh(III)‐catalyzed C−H activation of arenes and C−C cleavage of cyclopropanols. This method has a wide range of benzyl/phenyl substrate applicability and provides a theoretical guidance for our research to study quinazoline compounds.

中文翻译：

铑（III）在环境温度下指导C-H活化和开环反应，催化2-芳基喹唑啉-4（3H）-1与环丙醇的烷基化

开发了一种有效的方法，用于将2-芳基喹唑啉-4（3H）-one与环丙醇烷基化。通过Rh（III）催化的芳烃的CH活化和环丙醇的CC裂解合成了带有喹唑啉-4（3H）-1骨架的所需产物β-芳基酮。该方法具有广泛的苄基/苯基底物适用性，为我们研究喹唑啉化合物的研究提供了理论指导。

更新日期：2021-01-18

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