Histamine is one of the important biomarkers for food spoilage in the food sectors. In the present study, a rapid and simple analytical tool has been developed to detect histamine as an indirect strategy to monitor food freshness level. Optical histamine sensor with carboxyl-substituted Schiff base zinc(II) complex with hydroxypropoxy side chain deposited onto titanium dioxide nanoparticles was fabricated and was found to respond successfully to histamine. The Schiff base zinc(II) complex-histamine binding generated an enhancement of the fluorescent signal. Under the optimal reaction condition, the developed sensor can detect down to 2.53 × 10^-10 M in the range of between 1.0 × 10^-9 and 1.0 × 10^-5 M (R² = 0.9868). Selectivity performance of the sensor towards histamine over other amines was confirmed. The sensor also displayed good reproducibility performances with low relative standard deviation values (1.45%–4.95%). Shelf-life studies suggested that the developed sensor remains stable after 60 days in histamine detection. More importantly, the proposed sensor has been successfully applied to determine histamine in salmon fillet with good recoveries. This strategy has a promising potential in the food quality assurance sectors, especially in controlling the food safety for healthy consumption among consumers.

组胺是食品工业中食品变质的重要生物标志之一。在本研究中，已开发出一种快速简单的分析工具来检测组胺，作为监测食品新鲜度的间接策略。制备了具有羧基取代的席夫碱锌（II）配合物和羟基丙氧基侧链的光学组胺传感器，该复合物沉积在二氧化钛纳米颗粒上，并被发现对组胺具有成功的响应。席夫碱锌（II）复合物-组胺结合产生了荧光信号的增强。在最佳反应条件下，开发的传感器可以检测到2.53×10 ^-10 M，范围为1.0×10 ^-9到1.0×10 ^-5 M（R ²= 0.9868）。证实了传感器对组胺的选择性优于其他胺。该传感器还显示出良好的重现性，相对标准偏差值低（1.45％–4.95％）。保质期研究表明，开发的传感器在检测组胺60天后仍保持稳定。更重要的是，所提出的传感器已经成功地用于测定鲑鱼片中的组胺，回收率良好。该战略在食品质量保证部门，特别是在控制食品安全性以促进消费者健康消费方面具有广阔的潜力。