Fibroblast growth factor family (FGFs) is a kind of cytokine that plays an important role in growth, development, metabolism and disease. During bone development, multiple FGFs and fibroblast growth factor receptors (FGFRs) play important roles. Previous reports have elucidated the great importance of FGF1, 2, 4, 6, 7, 8, 9, 10, and 18 in bone development, and FGF21 and 23 in bone homeostasis and bone regulation. FGF19 was initially found in the human foetal brain, and its gene location is related to osteoporosis pseudoglioma syndrome. Presently, gene chip detection has repeatedly found that FGF19 shows spatiotemporal specificity of gene expression in bone development and bone-related diseases, as well as differences in the protein level, indicating that FGF19 affects the skeletal system. Considering the current insufficient understanding of FGF19 and its potential function in the skeletal system, this review aims to introduce the background of FGF19 in bone, summarise the research progress of FGF19 in the skeletal system, and discuss the role and therapeutic potential of FGF19 in bone development and bone-related diseases.

成纤维细胞生长因子家族（FGFs）是一种在生长，发育，代谢和疾病中起重要作用的细胞因子。在骨骼发育过程中，多种FGF和成纤维细胞生长因子受体（FGFR）发挥着重要作用。先前的报道阐明了FGF1、2、4、6、7、8、9、10和18在骨骼发育中以及FGF21和23在骨骼稳态和骨骼调节中的重要性。FGF19最初在人类胎儿脑中发现，其基因位置与骨质疏松假神经胶质瘤综合征有关。目前，基因芯片检测已反复发现，FGF19在骨骼发育和骨相关疾病中显示基因表达的时空特异性，以及蛋白质水平的差异，表明FGF19影响骨骼系统。