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Examining prefrontal contributions to past- and future-oriented memory disturbances in daily life in dementia
Cortex ( IF 3.6 ) Pub Date : 2020-11-24 , DOI: 10.1016/j.cortex.2020.11.003
Lulu Liu 1 , Daniel Roquet 1 , Rebekah M Ahmed 2 , John R Hodges 3 , Olivier Piguet 1 , Muireann Irish 1
Affiliation  

Deficits in episodic memory are commonplace in dementia, yet mounting evidence indicates pervasive impairments in future-oriented thinking in these syndromes. How such impairments manifest in the daily lives of people with dementia remain unclear, as do their neural bases. This study aimed to determine the neurocognitive mechanisms of past- and future-oriented memory performance across a large sample of dementia syndromes, each of which is characterised by distinct clinical and cognitive profiles. Carer-rated memory changes in everyday life in Alzheimer's disease, behavioural-variant frontotemporal dementia, semantic dementia, progressive non-fluent aphasia, and logopenic progressive aphasia were assessed using the Prospective and Retrospective Memory Questionnaire (PRM-Q). Participants underwent neuropsychological testing and whole-brain structural MRI. Relative to Controls, past- and future-oriented memory were compromised exclusively in AD and bvFTD, with no impairments reported for the other groups. For AD, atrophy in a distributed network of prefrontal, lateral and medial temporal regions including the hippocampus, correlated with past- and future-oriented memory impairments. In contrast, lateral and medial prefrontal regions correlated with past- and future-oriented memory difficulties in bvFTD. Notably, the orbitofrontal cortex emerged as a common neural substrate implicated in memory disturbances across the AD and bvFTD groups. This study confirms the presence of episodic amnesia in bvFTD across a host of everyday activities, mirroring the profile typically observed in AD. Of note, the orbitofrontal cortex emerged as a common region implicated in past- and future-oriented memory deficits in both patient groups, underscoring a critical role for prefrontal regions in supporting complex aspects of memory function in everyday life.



中文翻译:

检查前额叶对痴呆症患者日常生活中过去和未来的记忆障碍的影响

情景记忆的缺陷在痴呆症中很常见,但是越来越多的证据表明这些综合征的未来导向思维普遍受损。目前尚不清楚这种障碍在痴呆症患者的日常生活中如何表现出来,以及他们的神经基础也不清楚。这项研究旨在确定大量痴呆综合征样本在过去和未来的记忆表现的神经认知机制,每种样本都具有不同的临床和认知特征。使用前瞻性和回顾性记忆问卷调查(PRM-Q)评估了阿尔茨海默氏病,行为变异性额颞痴呆,语义性痴呆,进行性非流利性失语症和渐进性渐进性失语症患者日常生活中照顾者评分的记忆变化。参加者进行了神经心理学测试和全脑结构MRI。相对于对照,过去和未来的记忆仅在AD和bvFTD中受到损害,其他组没有受损的报道。对于AD,包括海马在内的前额叶,外侧和内侧颞叶区域的分布式网络中的萎缩与过去和将来的记忆障碍相关。相反,外侧和内侧前额叶区域与bvFTD中过去和将来的记忆困难相关。值得注意的是,眶额叶皮质是一种常见的神经基质,与AD和bvFTD组的记忆障碍有关。这项研究证实了bvFTD在许多日常活动中都存在阵发性健忘症,这反映了AD中通常观察到的情况。值得注意的是

更新日期:2020-12-14
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