A clear definition of developmentally incompetent preimplantation embryo (DIPE) in literature is still missing, while several scientific societies are discussing this challenging topic. From both a clinical and scientific perspective, the identification of embryos unfit for reproductive purpose is crucial. This aim should be pursued in light of all diagnostic technologies for embryo evaluation, encompassing also genetic analyses, of recent implementation in IVF. The Italian context is characterized by an unusual scenario: embryos can be discarded only if not viable and cannot be used for research purposes either. Therefore, thousands of embryos, diagnosed as affected and/or aneuploid as resulting from preimplantation genetic testing (PGT) and clinically not utilizable, are cryopreserved and stored indefinitely, with important psychological, legal, and financial implications. With the aim of updating the definition of DIPE, also on the basis of the embryo genetic status, the Italian Society of Embryology, Reproduction and Research (SIERR) and the Italian Society of Human Genetic (SIGU) reviewed the literature on this topic, found a consensus, and produced a list of relevant criteria.

文献中仍然缺乏对发育不全的植入前胚胎（DIPE）的明确定义，而一些科学协会正在讨论这个具有挑战性的话题。从临床和科学的角度来看，识别不适合生殖目的的胚胎至关重要。这一目标应该根据最近在体外受精中实施的所有胚胎评估诊断技术（包括遗传分析）来实现。意大利的情况有一个不寻常的情况：胚胎只有在无法存活且不能用于研究目的时才可以被丢弃。因此，成千上万个因植入前基因检测（PGT）而被诊断为受影响和/或非整倍体且临床上不可利用的胚胎被冷冻保存并无限期保存，这具有重要的心理、法律和财务影响。为了更新 DIPE 的定义，并根据胚胎遗传状态，意大利胚胎学、生殖和研究学会 (SIERR) 和意大利人类遗传学学会 (SIGU) 审查了有关该主题的文献，发现达成共识，并制定了相关标准清单。