Cerebral ischemic injury as the main manifestation of stroke can occur in stroke patients (70–80%). Nowadays, the main therapeutic strategy used for ischemic brain injury treatment aims to achieve reperfusion, neuroprotection, and neurorecovery. Also, angiogenesis as a therapeutic approach maybe represents a promising tool to enhance the prognosis of cerebral ischemic stroke. Unfortunately, although many therapeutic approaches as a life-saving gateway for cerebral ischemic injuries like pharmacotherapy and surgical treatments are widely used, they all fail to restore or regenerate damaged neurons in the brain. So, the suitable therapeutic approach would focus on regenerating the lost cells and restore the normal function of the brain. Currently, stem cell-based regenerative medicine introduced a new paradigm approach in cerebral ischemic injuries treatment. Today, in experimental researches, different types of stem cells such as mesenchymal stem cells have been applied. Therefore, stem cell-based regenerative medicine provides the opportunity to inquire and develop a more effective and safer therapeutic approach with the capability to produce and regenerate new neurons in damaged tissues.

脑缺血性损伤是脑卒中的主要表现（70%～80%）。目前，用于缺血性脑损伤治疗的主要治疗策略旨在实现再灌注、神经保护和神经恢复。此外，血管生成作为一种治疗方法可能代表了一种有前途的工具，可以提高脑缺血性卒中的预后。不幸的是，尽管药物治疗和手术治疗等作为脑缺血损伤挽救生命途径的许多治疗方法被广泛使用，但它们都无法恢复或再生大脑中受损的神经元。因此，合适的治疗方法将侧重于再生丢失的细胞并恢复大脑的正常功能。目前，基于干细胞的再生医学为脑缺血损伤的治疗引入了一种新的范式方法。今天，在实验研究中，已经应用了不同类型的干细胞，如间充质干细胞。因此，基于干细胞的再生医学为探索和开发更有效、更安全的治疗方法提供了机会，能够在受损组织中产生和再生新的神经元。