Due to the severity of infections caused by P. aeruginosa and the limitations in treatment, it is necessary to find new therapeutic alternatives. Thus, the use of silver nanoparticles (AgNPs) is a viable alternative because of their potential actions in the combat of microorganisms, showing efficacy against Gram-positive and Gram-negative bacteria, including multidrug-resistant microorganisms (MDR). In this sense, the aim of this work was to conduct a literature review related to the antibacterial and antibiofilm activity of AgNPs against antibiotic-sensitive and multidrug-resistant Pseudomonas aeruginosa strains. The AgNPs are promising for future applications, which may match the clinical need for effective antibiotic therapy. The size of AgNPs is a crucial element to determine the therapeutic activity of nanoparticles, since smaller particles present a larger surface area of contact with the microorganism, affecting their vital functioning. AgNPs adhere to the cytoplasmic membrane and cell wall of microorganisms, causing disruption, penetrating the cell, interacting with cellular structures and biomolecules, and inducing the generation of reactive oxygen species and free radicals. Studies describe the antimicrobial activity of AgNPs at minimum inhibitory concentration (MIC) between 1 and 200 μg/mL against susceptible and MDR P. aeruginosa strains. These studies have also shown antibiofilm activity through disruption of biofilm structure, and oxidative stress, inhibiting biofilm growth at concentrations between 1 and 600 μg/mL of AgNPs. This study evidences the advance of AgNPs as an antibacterial and antibiofilm agent against Pseudomonas aeruginosa strains, demonstrating to be an extremely promising approach to the development of new antimicrobial systems.

中文翻译：

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银纳米粒子对抗生素敏感和多重耐药铜绿假单胞菌菌株的抗菌和抗生物膜潜力

由于铜绿假单胞菌引起的感染的严重性和治疗的局限性，有必要寻找新的治疗选择。因此，银纳米粒子 (AgNPs) 的使用是一种可行的替代方案，因为它们在对抗微生物方面具有潜在作用，对革兰氏阳性和革兰氏阴性细菌，包括多药耐药微生物 (MDR) 显示出功效。从这个意义上说，这项工作的目的是进行与 AgNPs 对抗生素敏感和多重耐药铜绿假单胞菌菌株的抗菌和抗生物膜活性相关的文献综述。AgNPs 有望用于未来的应用，这可能符合对有效抗生素治疗的临床需求。AgNPs 的大小是决定纳米粒子治疗活性的关键因素，因为较小的颗粒与微生物接触的表面积较大，从而影响它们的重要功能。AgNPs 粘附在微生物的细胞质膜和细胞壁上，引起破坏，穿透细胞，与细胞结构和生物分子相互作用，并诱导活性氧和自由基的产生。研究描述了 AgNPs 在 1 和 200 μg/mL 之间的最小抑制浓度 (MIC) 对敏感和 MDR 铜绿假单胞菌菌株的抗菌活性。这些研究还通过破坏生物膜结构和氧化应激显示了抗生物膜活性，在 1 至 600 μg/mL 的 AgNPs 浓度下抑制生物膜生长。这项研究证明了 AgNPs 作为抗铜绿假单胞菌菌株的抗菌和抗生物膜剂的进展，