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Fabrication, toxicity and biocompatibility of Sesamum indicum infused graphene oxide nanofiber - a novel green composite method
Applied Nanoscience Pub Date : 2020-11-24 , DOI: 10.1007/s13204-020-01596-4
Sivaranjani Sivalingam , Arya Kunhilintakath , Ponpandian Nagamony , Vijaya Paspulathi Parthasarathy

Development of highly improved or reinforced Graphene oxide nanosheets were synthesized by converting it into a whole green GO nanofiber material and by infusing the aqueous seed extracts of Sesamum indicum (SI), along with the fiber generation process of GO. The synthesized GO nanofibers (NF) and GO/SI NF were characterized for structural, morphological, elemental and functional group analysis. The antimicrobial and biocompatible nature of GO/SI NF was evaluated in comparison with GO NF. The results showed the non-toxic nature of both the nanofibers (GO NF and GO/SI NF) on gram-negative bacteria (Klebsiella oxytoca) and gram-positive bacteria (Staphylococcus aureus). Both the nanofibers were hemo-/biocompatible toward human red blood cells and human epithelial cell lines (TH 1); however, the hemo-/biocompatibility was further increased after the addition of SI into GO NF, and therefore, GO/SI NF can be a potent green nanofiber material for the biomedical applications.



中文翻译:

芝麻注入氧化石墨烯纳米纤维的制备,毒性和生物相容性-一种新型的绿色复合方法

通过将其转变为完整的绿色GO纳米纤维材料,并注入印度芝麻(SI)的含水种子提取物,以及GO的纤维生成过程,来合成高度改良或增强的氧化石墨烯纳米片。对合成的GO纳米纤维(NF)和GO / SI NF进行了结构,形态,元素和官能团分析。与GO NF相比,对GO / SI NF的抗菌和生物相容性进行了评估。结果表明,纳米纤维(GO NF和GO / SI NF)对革兰氏阴性菌(克雷伯氏菌)和革兰氏阳性菌(金黄色葡萄球菌)均无毒。)。两种纳米纤维都对人红细胞和人上皮细胞系具有血液/生物相容性(TH 1)。但是,在GO NF中加入SI后,血液/生物相容性进一步提高,因此,GO / SI NF可以成为用于生物医学应用的有效绿色纳米纤维材料。

更新日期:2020-11-25
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