Many recent studies have reported that patients infected with novel coronavirus 2019 or SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) might have a liver injury. However, few studies have focussed on the levels of Gamma glutamyl-transferase (GGT) alone and the variations associated with it. We retrospectively analysed the GGT levels of 476 admitted patients with confirmed COVID-19 in a tertiary care centre, PGIMER (Post Graduate Institute of Medical Education and Research), Chandigarh. Out of the total 476 COVID-19 patients studied, 35% had elevated GGT levels. ICU care was required for 51.19% (P <0.0001) of these patients and their hospital stay was of longer duration as compared to the patients with normal GGT levels. The incidence of GGT elevation was found to be more pronounced in males and elderly patients. The male population displayed higher GGT levels with 52% having raised levels compared to females where only 21.6% had elevated GGT levels. Although the number of COVID-19 cases was majorly from young age groups, the elevation in GGT levels has been reported more in elderly patients. GGT levels can therefore serve as a predictor for the extent of liver injury and severity in COVID-19 patients.

中文翻译：

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评估COVID-19中γ-谷氨酰转移酶（GGT）的水平：三级护理中心的回顾性分析

最近的许多研究报告称，感染了新型冠状病毒2019或SARS-CoV-2（严重急性呼吸系统综合症冠状病毒2）的患者可能患有肝损伤。但是，很少有研究集中在单独的Gamma谷氨酰转移酶（GGT）的水平及其相关变化上。我们回顾性分析了昌迪加尔市三级医疗中心PGIMER（医学教育与研究研究生学院）的476例确诊COVID-19的入院患者的GGT水平。在研究的总共476名COVID-19患者中，有35％的GGT水平升高。重症监护病房需要51.19％（P与具有正常GGT水平的患者相比，这些患者的<0.0001）住院时间更长。发现GGT升高的发生在男性和老年患者中更为明显。男性人群的GGT水平较高，其中52％的人群的GGT水平升高，而女性人群中GGT水平的比例仅为21.6％。尽管COVID-19病例的数量主要来自年轻人，但据报道，老年患者的GGT水平升高更多。因此，GGT水平可作为COVID-19患者肝损伤程度和严重程度的预测指标。