Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global pandemic in 2020 resulting a massive morbidity & mortality. The lung is the predominant organ involved in symptomatic patients with Coronavirus disease-2019 (COVID-19) along with involvement of other organs. Understanding the histopathological changes of lung and other organs in COVID-19 become essential for not only formulating future management protocols but also for determing prognosis. The collection of potentially contaminated tissues during the autopsy and further processing of them in histopathology laboratory with proper maintenance of safety protocol is of immense importance. A review of the available scientific articles shows the diffuse alveolar damage and microvascular thrombi are common observation found in lung tissue in patients who died due to COVID-19.

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COVID-19的组织病理学基础：简短回顾

严重的急性呼吸系统综合症冠状病毒2（SARS-CoV-2）是2020年全球大流行的诱因，导致大量发病和死亡。肺部是有症状冠状病毒病-2019（COVID-19）的有症状患者以及其他器官的主要累及器官。了解肺和其他器官中COVID-19的组织病理学变化不仅对制定未来的治疗方案而且对确定预后至关重要。在尸检过程中收集可能受污染的组织，并在组织病理学实验室中对它们进行进一步处理，并妥善维护安全规程，这一点极为重要。