Cadmium is a heavy metal widely used in human life. When it enters the body, cadmium might bind to metallothionein protein and impair renal function. The renal function decrease usually is characterized by raise of β2-microglobulin, creatinine, ureum and uric acid levels, which possibly be cured by lycopene, and antioxidant found in tomato. The objective of the study was to determine the effective lycopene dose as a renoprotective of Cd exposure. Twenty four Wistar rats used in this study were divided into six groups (four individuals in each group). Group I was the negative control, Group II was given 5.6 mg/kgBW CdSO4 as a positive control. Group III, IV and V were given 5.6 mg/kgBW CdSO4 and tomato extract of 0.36, 0.72 and 1.08 mg/kgBW/day respectively. Group VI exposed to CdSO4, and after seven days an additional 0.3 mg/kgBW/day of dimercaprol was administered for 14 days as a comparison to tomato. The parameters observed were levels of Cd, creatinine, and β2-microglobulin in blood level. Observations were made on day 0 and day 22. The data were analyzed by ANOVA (F-test), followed by the Duncan test. The results showed that all treatments and dimercaprol could reduce the levels of Cd, creatinine, ureum, uric acid, and β2-Microglobulin. The optimal decrease was observed in the rats administered with 1.08 mg/kgBW/day. Tomato extract dose 1.08 mg/kgBW was the highest in lowering levels of blood Cd, β2-M, creatinine, urea, and uric acid levels.

镉是一种广泛用于人类生活的重金属。当它进入体内时，镉可能与金属硫蛋白结合并损害肾功能。肾功能下降通常表现为β2-微球蛋白、肌酐、尿素和尿酸水平升高，这可能被番茄红素和番茄中的抗氧化剂治愈。该研究的目的是确定有效的番茄红素剂量作为镉暴露的肾脏保护剂。本研究中使用的 24 只 Wistar 大鼠分为六组（每组四只）。I组为阴性对照，II组给予5.6 mg/kgBW CdSO4作为阳性对照。III、IV 和 V 组分别给予 5.6 mg/kgBW CdSO4 和番茄提取物 0.36、0.72 和 1.08 mg/kgBW/天。第 VI 组暴露于 CdSO4，7 天后额外暴露 0。与番茄相比，给予 3 mg/kgBW/天的二巯基丙醇 14 天。观察到的参数是血液中 Cd、肌酐和 β2-微球蛋白的水平。在第 0 天和第 22 天进行观察。通过 ANOVA（F 检验）分析数据，然后进行 Duncan 检验。结果表明，所有治疗和二巯基丙醇均可降低镉、肌酐、尿素、尿酸和β2-微球蛋白的水平。在给予 1.08 mg/kgBW/天的大鼠中观察到最佳降低。番茄提取物剂量 1.08 mg/kgBW 在降低血液 Cd、β2-M、肌酐、尿素和尿酸水平方面最高。通过 ANOVA（F 检验）分析数据，然后进行 Duncan 检验。结果表明，所有治疗和二巯基丙醇均可降低镉、肌酐、尿素、尿酸和β2-微球蛋白的水平。在给予 1.08 mg/kgBW/天的大鼠中观察到最佳降低。番茄提取物剂量 1.08 mg/kgBW 在降低血液 Cd、β2-M、肌酐、尿素和尿酸水平方面最高。通过 ANOVA（F 检验）分析数据，然后进行 Duncan 检验。结果表明，所有治疗和二巯基丙醇均可降低镉、肌酐、尿素、尿酸和β2-微球蛋白的水平。在给予 1.08 mg/kgBW/天的大鼠中观察到最佳降低。番茄提取物剂量 1.08 mg/kgBW 在降低血液 Cd、β2-M、肌酐、尿素和尿酸水平方面最高。