Catalytic and electrocatalytic applications of supported metal nanoparticles are hindered due to an aggregation of metal nanoparticles and catalytic leaching under harsh operations. Hence, stable and leaching free catalysts with high surface area are extremely desirable but also challenging. Here we report a gold nanoparticles-hosted mesoporous nitrogen doped carbon matrix, which is prepared using bovine serum albumin (BSA) through calcination. BSA plays three roles in this process as a reducing agent, capping agent and carbon precursor, hence the protocol exhibits economic and sustainable. Gold nanoparticles at N-doped bovine serum albumin carbon (AuNPs@NBSAC)-modified three-electrode strip-based flexible sensor system has been developed, which displayed effective, sensitive and selective for simultaneous detection of uric acid (UA) and dopamine (DA). The AuNPs@NBSAC-modified sensor showed an excellent response toward DA with a linear response throughout the concentration range from 1 μM to 50 μM and a detection limit of 0.05 μM. It also exhibited an excellent response toward UA, with a wide detection range from 5 μM to 200 μM as well as a detection limit of 0.1 μM. The findings suggest that the AuNPs@NBSAC nanohybrid reveals promising applications and can be considered as potential electrode materials for development of electrochemical biosensors.

中文翻译：

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用于同时检测多巴胺和尿酸的柔性和一次性金纳米粒子-N-掺杂碳修饰电​​化学传感器

由于金属纳米颗粒的聚集和在苛刻操作下的催化浸出，负载型金属纳米颗粒的催化和电催化应用受到阻碍。因此，具有高表面积的稳定且无浸出的催化剂是非常理想的，但也具有挑战性。在这里，我们报告了一种以金纳米颗粒为载体的介孔氮掺杂碳基质，该基质是使用牛血清白蛋白 (BSA) 通过煅烧制备的。BSA 在此过程中作为还原剂、封端剂和碳前体发挥三个作用，因此该协议具有经济性和可持续性。N掺杂牛血清白蛋白碳（AuNPs@NBSAC）修饰的基于三电极条的柔性传感器系统已开发出金纳米粒子，该系统显示出有效，同时检测尿酸 (UA) 和多巴胺 (DA) 的灵敏度和选择性。AuNPs@NBSAC 修饰的传感器对 DA 表现出优异的响应，在 1 μM 至 50 μM 的浓度范围内具有线性响应，检测限为 0.05 μM。它对 UA 也表现出优异的响应，检测范围从 5 μM 到 200 μM，检测限为 0.1 μM。研究结果表明，AuNPs@NBSAC 纳米杂化物具有广阔的应用前景，可被视为开发电化学生物传感器的潜在电极材料。具有从 5 μM 到 200 μM 的宽检测范围以及 0.1 μM 的检测限。研究结果表明，AuNPs@NBSAC 纳米杂化物具有广阔的应用前景，可被视为开发电化学生物传感器的潜在电极材料。具有从 5 μM 到 200 μM 的宽检测范围以及 0.1 μM 的检测限。研究结果表明，AuNPs@NBSAC 纳米杂化物具有广阔的应用前景，可被视为开发电化学生物传感器的潜在电极材料。