The influence of high-intensity focused ultrasound (HIFU) reflected from a soft-tissue/bone interface on the temperature rise and lesion formation was theoretically and experimentally investigated in a soft-tissue/bone phantom. The acoustic intensities and the HIFU-induced temperature rises at the focal and the pre-focal regions were numerically simulated without and with the bone. Thermal ablation experiments in a soft-tissue/bone phantom were performed to validate the simulation results. It was found that the presence of a soft-tissue/bone interface in the HIFU beam path may enhance heating leading to the growth of the thermal lesion toward the HIFU source and the bone.

在软组织/骨模型中，从理论和实验上研究了从软组织/骨界面反射的高强度聚焦超声（HIFU）对温度升高和病变形成的影响。在无骨和有骨的情况下，通过数值模拟了焦点处和HIFU处的声强和HIFU诱导的温度升高。在软组织/骨模型中进行热消融实验以验证模拟结果。已经发现，在HIFU束路径中存在软组织/骨界面可以增强加热，导致热损伤向HIFU源和骨骼生长。