Photoaging is mainly induced by continuous exposure to sun light, causing multiple unwanted skin characters and accelerating skin aging. Adipose-derived stem cells(ADSCs) are promising in supporting skin repair because of their significant antioxidant capacity and strong proliferation, differentiation, and migration ability, as well as their enriched secretome containing various growth factors and cytokines. The identification of the mechanisms by which ADSCs perform these functions for photoaging has great potential to explore therapeutic applications and combat skin aging. We also review the basic mechanisms of UV-induced skin aging and recent improvement in pre-clinical applications of ADSCs associated with photoaging. Results showed that ADSCs are potential to address photoaging problem and might treat skin cancer. Compared with ADSCs alone, the secretome-based approaches and different preconditionings of ADSCs are more promising to overcome the current limitations and enhance the anti-photoaging capacity.

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脂肪干细胞在光老化中的应用：基础科学和文献综述

光老化主要是由持续暴露在阳光下引起的，从而导致多个不必要的皮肤特征并加速皮肤老化。脂肪干细胞（ADSCs）具有强大的抗氧化能力，强大的增殖，分化和迁移能力，以及富含各种生长因子和细胞因子的分泌蛋白，因此有望支持皮肤修复。识别ADSC执行这些功能以进行光老化的机制具有探索治疗用途和对抗皮肤衰老的巨大潜力。我们还审查了UV引起的皮肤衰老的基本机理以及与光老化相关的ADSC的临床前应用的最新进展。结果表明，ADSC具有解决光老化问题的潜力，并可能治疗皮肤癌。与仅ADSC相比，