Intervertebral disc degeneration (IDD) is a globally occurring disease that represents a significant cause of socioeconomic problems. Currently, the main method for treating IDD is surgery, including discectomy and vertebral fusion. Several in vitro experiments demonstrated that platelet-rich plasma (PRP) could stimulate cell proliferation and extracellular matrix regeneration. Additionally, in vivo experiments have proven that PRP injection could restore intervertebral disc height. Clinical studies demonstrated that PRP injection could significantly relieve patient pain. However, further studies are still required to clarify the roles of PRP in IDD prevention and treatment. This review is aimed at summarizing and critically analyzing the current evidence regarding IDD treatment with PRP.

中文翻译：

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富血小板血浆对体内和体外椎间盘退变的影响：一项重要的评论。

椎间盘退变（IDD）是一种全球性疾病，代表了社会经济问题的重要原因。当前，治疗IDD的主要方法是手术，包括椎间盘切除术和椎骨融合术。几个体外实验表明，富含血小板的血浆（PRP）可以刺激细胞增殖和细胞外基质再生。此外，体内实验证明，PRP注射可以恢复椎间盘高度。临床研究表明，PRP注射可以显着减轻患者的痛苦。但是，仍然需要进一步的研究来阐明PRP在IDD预防和治疗中的作用。这篇综述旨在总结和批判性地分析有关IDP治疗PRP的当前证据。