Astrocytes play a crucial role in neuronal firing activity. Their abnormal state may lead to the pathological transition of neuronal firing patterns and even induce seizures. However, there is still little evidence explaining how the astrocyte network modulates seizures caused by structural abnormalities, such as gliosis. To explore the role of gliosis of the astrocyte network in epileptic seizures, we first established a direct astrocyte feedback neuronal network model on the basis of the hippocampal CA3 neuron-astrocyte model to simulate the condition of gliosis when astrocyte processes swell and the feedback to neurons increases in an abnormal state. We analyzed the firing pattern transitions of the neuronal network when astrocyte feedback starts to change via increases in both astrocyte feedback intensity and the connection probability of astrocytes to neurons in the network. The results show that as the connection probability and astrocyte feedback intensity increase, neuronal firing transforms from a nonepileptic synchronous firing state to an asynchronous firing state, and when astrocyte feedback starts to become abnormal, seizure-like firing becomes more severe and synchronized; meanwhile, the synchronization area continues to expand and eventually transforms into long-term seizure-like synchronous firing. Therefore, our results prove that astrocyte feedback can regulate the firing of the neuronal network, and when the astrocyte network develops gliosis, there will be an increase in the induction rate of epileptic seizures.

中文翻译：

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由异常星形胶质细胞反馈维持的神经元网络放电的动态转换

星形胶质细胞在神经元放电活动中起着至关重要的作用。它们的异常状态可能导致神经元放电模式的病理转变，甚至诱发癫痫发作。然而，仍然没有证据解释星形胶质细胞网络如何调节由结构异常（如神经胶质增生）引起的癫痫发作。为探讨星形胶质细胞网络胶质增生在癫痫发作中的作用，我们首先在海马CA3神经元-星形胶质细胞模型的基础上建立了星形胶质细胞直接反馈神经元网络模型，以模拟星形胶质细胞突起肿胀时的胶质增生状态以及对神经元的反馈。在异常状态下增加。我们分析了当星形胶质细胞反馈通过增加星形胶质细胞反馈强度和星形胶质细胞与网络中神经元的连接概率开始改变时神经元网络的放电模式转换。结果表明，随着连接概率和星形胶质细胞反馈强度的增加，神经元放电从非癫痫性同步放电状态转变为异步放电状态，当星形胶质细胞反馈开始异常时，癫痫样放电变得更加严重和同步；同时，同步区域不断扩大，最终转变为长时间的癫痫样同步点火。因此，我们的结果证明星形胶质细胞反馈可以调节神经元网络的放电，当星形胶质细胞网络发生胶质增生时，