Maintaining ignorance to self-nucleic acids can prevent inflammatory diseases such as Aicardi–Goutières syndrome (AGS). A new study finds that mutations in LSM11 and RNU7-1, which encode components of the histone messenger RNA–preprocessing complex, cause AGS by loosening the binding of cyclic GMP–AMP synthase (cGAS) to nucleosomes, thus enabling cGAS activation and induction of type I interferons.

中文翻译：

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放松对核cGAS的控制

保持对自身核酸的无知可以预防炎症性疾病，例如艾卡迪－古特雷斯综合症（AGS）。一项新研究发现，编码组蛋白信使RNA预处理复合物成分的LSM11和RNU7-1中的突变，可通过松散环状GMP-AMP合酶（cGAS）与核小体的结合而导致AGS，从而使cGAS活化和诱导I型干扰素。