Bio-Inspired Polymer Thin Films with Non-Close-Packed Nanopillars for Enhanced Bactericidal and Antireflective Properties,ACS Applied Polymer Materials

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Bio-Inspired Polymer Thin Films with Non-Close-Packed Nanopillars for Enhanced Bactericidal and Antireflective Properties
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-11-23 , DOI: 10.1021/acsapm.0c01054
Ruwen Tan ₁ , Nicolas Marzolini ₁ , Peng Jiang ₁ , Yeongseon Jang ₁

Affiliation

The perpetual health and safety concerns caused by bacterial adhesion on surfaces demand the development of next-generation antibacterial materials. Inspired by bactericidal surfaces on cicada wings with protrusive nanostructures, which induce mechanical rupture of adhered bacterial membranes without antibacterial, chemical treatments, analogous structures have been fabricated on various synthetic materials to achieve such mechanical bactericidal efficacy. Herein, we developed a series of protrusive nanopillars on hard silicon (Si) substrates and soft poly(ethylene glycol) diacrylate (PEGDA) thin films by colloidal lithography. We first investigated the correlation of interpillar distance and bactericidal efficacy against a model Gram-negative bacterium, Escherichia coli, using Si surfaces with different nanopillar number densities. We demonstrated that the bactericidal efficacy increased with decreasing nanopillar number density, which occurred when the average interpillar distance was smaller than the cell size. The bactericidal efficacy decreases when the average interpillar distance becomes larger than the comparable size of bacteria. We then designed PEGDA thin films with optimized bactericidal nanopillar density to improve their antibacterial and antireflective performance. The results indicate that the surface nanostructure plays a critical role in dictating antibacterial performance, regardless of the material type. This work provides insight into the understanding of physical interactions between nanostructured surfaces and bacterial cells as well as practical solutions for the development of antibacterial polymer surfaces for the application of optical lenses or screen displays to prevent public pathogenic infections.

中文翻译：

具有非紧密堆积纳米柱的生物启发聚合物薄膜，具有增强的杀菌和抗反射特性

由于细菌在表面上的附着而引起的永久性健康和安全问题，需要开发下一代抗菌材料。受具有突出的纳米结构的蝉翼上的杀菌表面的启发，这种表面在不进行抗菌，化学处理的情况下引起粘附的细菌膜的机械破裂，已经在各种合成材料上制造了类似的结构以实现这种机械杀菌功效。本文中，我们通过胶体光刻技术在硬质硅（Si）基板和软质聚乙二醇二丙烯酸酯（PEGDA）薄膜上开发了一系列凸出的纳米柱。我们首先研究了针对模型革兰氏阴性细菌大肠埃希氏菌的柱间距离与杀菌功效的相关性，使用具有不同纳米柱数密度的Si表面。我们证明了杀菌功效随着纳米柱数密度的降低而增加，纳米柱数密度的降低是在平均柱间距离小于细胞大小时发生的。当平均柱间距离变得大于可比细菌的大小时，杀菌功效就会降低。然后，我们设计了具有最佳杀菌纳米柱密度的PEGDA薄膜，以提高其抗菌和抗反射性能。结果表明，无论材料类型如何，表面纳米结构在决定抗菌性能方面都起着至关重要的作用。

更新日期：2020-12-11

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