Abstract

Among the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study included a total of 86 participants: 39 patients with AH and 47 healthy individuals. Serum HIF-1α levels (ng/mL) were measured by ELISA. HIF-1α concentrations were compared to the adenoid-nasopharyngeal ratio (ANR) of patients with AH, as recorded in the medical records. We found significantly higher concentrations of HIF-1α (0.30 ± 0.47 ng/mL) in patients with AH as compared to healthy controls (0.24 ± 0.07 ng/mL, p = .011). HIF-1α levels were not significantly different regarding gender between patients with AH (p = .77) and in the control group (p = .97). In patients with AH, there was a moderately significant positive correlation between HIF-1α levels and Hb (p = .000), (correlation coefficient r = 0.542). There was a positive correlation between HIF-1α and ANR in patients with AH (p = .005, r = 0.439). This study indicates that AH increases HIF-1α levels. We also observed a moderately significant positive correlation between HIF-1α and ANR in patients with AH. HIF-1α levels are a potential biomarker for hypoxia in patients with AH.

摘要

儿童时期最常见的鼻充血原因是腺样体肥大（AH），可导致缺氧。在这项研究中，我们研究了接受腺样体切除术的儿童的低氧诱导因子-1α（HIF-1α）的血浆浓度。该研究共包括86名参与者：39名AH患者和47名健康个体。通过ELISA测量血清HIF-1α水平（ng / mL）。根据病历记录，将HIF-1α浓度与AH患者的腺样体-鼻咽比率（ANR）进行比较。我们发现，与健康对照组（0.24±0.07 ng / mL，p  = 0.011）相比，AH患者的HIF-1α浓度明显更高（0.30±0.47 ng / mL ）。AH患者之间HIF-1α水平在性别方面无显着差异（p = .77）和对照组（p  = .97）。在AH患者中，HIF-1α水平与Hb之间存在中等程度的正相关（p  = .000）（相关系数r  = 0.542）。AH患者中HIF-1α与ANR之间呈正相关（p  = .005，r  = 0.439）。这项研究表明AH可增加HIF-1α水平。我们还观察到AH患者中HIF-1α和ANR之间存在中等程度的正相关。HIF-1α水平是AH患者缺氧的潜在生物标志物。