ABSTRACT

The solubility of paracetamol in the ternary mixtures of water + ethanol + glycerol at 298.2 and 303.2 K is determined via the shake-flask method. The reported data extend the solubility database for paracetamol in various solvent mixtures and also is employed to investigate the prediction capability of the cosolvency models for solubility prediction in the sub-binary and the ternary solvent systems. The solubility data are correlated with some cosolvency models and their accuracies are evaluated by the mean relative deviation (MRD) computed for back-calculated solubilities. The results show that the investigated models fit well and can be applied to the ternary solvent system, and the experimental data is relatively more consistent with the calculated values. The prediction ability of the trained Jouyban-Acree model for predicting drug solubility behaviour in the corresponding sub-binary systems is also investigated.

摘要

通过摇瓶法测定对乙酰氨基酚在水+乙醇+甘油在298.2和303.2 K的三元混合物中的溶解度。报告的数据扩展了扑热息痛在各种溶剂混合物中的溶解度数据库，还用于研究共溶剂模型在亚二元和三元溶剂系统中的溶解度预测的预测能力。溶解度数据与某些共融模型相关联，并通过平均相对偏差（MRD）计算得出的反向溶解度。结果表明，所研究的模型拟合良好，可以应用于三元溶剂体系，实验数据与计算值相对更一致。还研究了训练后的Jouyban-Acree模型在相应子二元系统中预测药物溶解度行为的预测能力。