Abstract

Two new compounds named epipaxilline (1) and penerpene J (2) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC₅₀ values of 31.5 and 9.5 μM, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC₅₀ value of 14.7 μM.

中文翻译：

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来自海洋真菌Penicillium sp。的两种新的吲哚-二萜类化合物。KFD28

摘要

从海洋真菌Penicillium sp。中分离出了两种新的化合物命名为epipaxilline（1）和penerpene J（2）。KFD28。它们的结构包括绝对构型是根据光谱法和ECD分析确定的。化合物1和2对PTP1B的抑制活性分别为IC ₅₀值为31.5和9.5μM，化合物2对TCPTP的抑制活性也为IC ₅₀值为14.7μM 。