ABSTRACT

Introduction: Cancer has always been a menace for the society. Hepatocellular carcinoma (HCC) is one of the most lethal and 3rdlargest causes of deaths around the world.

Area covered: The emergence of natural actives is considered as the greatest boon for fighting cancer. The natural actives take precedence over the traditional chemotherapeutic drugs in terms of their multi-target, multi-level and coordinated effects in the treatment of HCC. Literature reports have indicated the tremendous potential of bioactive natural products in inhibiting the HCC via molecular drug targeting, augmented bioavailability, and the ability for both passive or active targeting and stimulus-responsive drug release characteristics. This review provides a newer treatment approaches involved in the mechanism of action of different natural actives used for the HCC treatment via different molecular pathways. Besides, the promising advantage of natural bioactive-loaded nanocarriers in HCC treatment has also been also presented in this review.

Expert opinion: The remarkable outcomes have been observed with therapeutic efficacy of the nanocarriers of natural actives in the treatment of HCC.Furthermore, it requires a thorough assessment of the safety and efficacy evaluation of the nanocarriers for the delivery of targeted natural active ingredients in HCC.]

摘要

简介：癌症一直是社会的威胁。肝细胞癌（HCC）是世界上最致命的死亡原因之一，也是第三大死亡原因。

覆盖面积：天然活性物质的出现被认为是对抗癌症的最大福音。就其在HCC治疗中的多靶点，多水平和协同作用而言，天然活性物质优先于传统的化学治疗药物。文献报道表明，生物活性天然产物具有通过分子药物靶向抑制HCC的巨大潜力，更高的生物利用度以及被动或主动靶向能力以及刺激反应性药物释放特性。这篇综述提供了一种新的治疗方法，涉及通过不同分子途径用于HCC治疗的不同天然活性物质的作用机理。此外，本综述还介绍了天然生物活性纳米载体在肝癌治疗中的有前途的优势。

专家意见：天然活性物纳米载体在肝癌治疗中的疗效已观察到显着结果，此外，还需要对纳米载体在HCC中靶向天然活性成分的安全性和功效评估进行全面评估。]