Chemokine receptors and their corresponding ligands are key players of immunity by regulation of immune cell differentiation and migration. CXCR1 is a high‐affinity receptor for CXCL8. Differential expression of CXCR1 is associated with a variety of human pathologies including cancer and inflammatory diseases. While various studies have highlighted the importance of CXCR1‐mediated CXCL8‐sensing for neutrophil trafficking and function, its role in B‐cell responses remains unsolved. Therefore, our aim was to investigate innate and adaptive antibody responses in CXCR1‐deficient mice.

中文翻译：

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增强 IgG1 介导的对 CXCR1 缺陷小鼠胸腺依赖性免疫的抗体反应

趋化因子受体及其相应的配体通过调节免疫细胞分化和迁移而成为免疫的关键参与者。CXCR1 是 CXCL8 的高亲和力受体。CXCR1 的差异表达与多种人类病理学有关，包括癌症和炎症性疾病。虽然各种研究强调了 CXCR1 介导的 CXCL8 传感对中性粒细胞运输和功能的重要性，但其在 B 细胞反应中的作用仍未得到解决。因此，我们的目标是研究 CXCR1 缺陷小鼠的先天和适应性抗体反应。