Dried blood spots for anti‐doping: Why just going volumetric may not be sufficient,Drug Testing and Analysis

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Dried blood spots for anti‐doping: Why just going volumetric may not be sufficient
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-11-17 , DOI: 10.1002/dta.2977
Marc Luginbühl ₁ , Stefan Gaugler ₁

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The perspective discusses quantitative DBS analysis for anti‐doping testing in an athletic population and why only using volumetric sampling for this subgroup might not be enough. It presents examples to highlight where HCT variations occur, followed by a whole blood to plasma ratio and an HCT extraction bias discussion. Finally, options to correct for the HCT bias are presented.

中文翻译：

用于反兴奋剂的干血斑：为什么仅仅进行体积测量可能还不够

该观点讨论了在运动人群中进行反兴奋剂检测的定量 DBS 分析，以及为什么仅对该亚组使用体积抽样可能还不够。它提供了一些例子来强调 HCT 变异发生的地方，然后是全血与血浆的比率和 HCT 提取偏差讨论。最后，提出了纠正 HCT 偏差的选项。

更新日期：2021-01-18

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