Local chemotherapy is increasingly used, either in combination with surgery or as monotherapy, for management of ocular tumors. Yet many of the local chemotherapeutic agents used for ocular tumors are cytotoxic drugs that are frequently associated with toxicities in normal ocular tissues. Understanding and managing these side effects are important because they affect treatment tolerability, outcome and quality of vision. Herein, we review local anticancer drugs administered for the treatment of ocular tumors, with an emphasis on their toxicities to the ocular surface, adnexa and lacrimal drainage system. We provide the underlying mechanisms and management strategies for the ocular side effects. Recent innovations in anticancer immunotherapy and ocular drug delivery systems also are discussed as new potential therapeutic modalities for alleviation of side effects.

局部化疗越来越多地与手术结合或作为单一疗法用于眼肿瘤的治疗。然而，用于眼肿瘤的许多局部化学治疗剂是细胞毒性药物，其通常与正常眼组织的毒性有关。了解和管理这些副作用非常重要，因为它们会影响治疗耐受性，结果和视觉质量。本文中，我们综述了用于治疗眼部肿瘤的局部抗癌药物，重点是其对眼表，附件和泪道引流系统的毒性。我们提供了眼部副作用的潜在机制和治疗策略。