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Zoonotic Taenia infections with focus on cysticercosis due to Taenia solium in swine and humans
Research in Veterinary Science ( IF 2.2 ) Pub Date : 2020-11-22 , DOI: 10.1016/j.rvsc.2020.11.015
Fela Mendlovic , Agnes Fleury , Ana Flisser

Zoonotic taeniasis caused by the adult stage of Taenia solium, Taenia saginata or Taenia asiatica are considered neglected tropical diseases by the World Health Organization. The life cycle of these 3 metazoan species is very similar and includes an intermediate host: pigs in the case of T. solium and T. asiatica, and cattle in the case of T. saginata. By eating meat (pork/T. solium, T. asiatica; beef/T. saginata) containing live cysticerci, humans develop taeniasis, which is practically asymptomatic but is the main risk factor for intermediate hosts to become infected. T. saginata causes bovine cysticercosis, while T. solium and T. asiatica cause swine cysticercosis, of veterinary and economic importance. T. solium cysticerci cause neurological disease in humans: neurocysticercosis. Cysticerci develop after ingesting microscopic eggs released from a human tapeworm carrier. Here we describe the life stages of the parasites, diagnosis, pathogenesis, symptomatology of neurocysticercosis, and prevention and control measures. Highlighting the need to validate diagnostic tools, treatments and vaccination in endemic areas, with the challenge of addressing the most vulnerable populations that lack resources. If people understand the transmission route, avoid eating uncooked or insufficiently cooked meat and have adequate hygienic habits, the life cycle of the 3 zoonotic Taenia species may be interrupted. In addition, we describe the growing field of immune response and immunomodulation elicited by the parasites, which may provide essential tools for diagnosis, treatment, control of taeniasis/cysticercosis, as well as for identification of parasite-derived immunomodulators that could aid in the treatment of emerging inflammatory diseases worldwide.



中文翻译:

猪和人的牛带Ta虫引起的人畜共患性牛带en虫感染以囊虫病为重点

Taenia soliumTaenia saginataTaenia asiatica的成年阶段引起的人畜共患的en虫病被世界卫生组织视为被忽视的热带病。这3个后生动物的生命周期非常相似,并且包括一个中间宿主:对于T. soliumT. asiatica来说,对于T. saginata来说是牛。通过进食含有活囊虫的肉(猪肉/茄形。,亚洲锥asia;牛肉/茄形sa),人会患上en虫病,这种病实际上无症状,但是中间宿主被感染的主要危险因素。杉杉引起牛囊尾rc病,而猪毛囊尾asia积雪草引起猪囊尾rc病,具有兽医和经济意义。so虫胱氨酸导致人类神经系统疾病:神经囊尾osis病。囊尾虫在摄取从人tape虫载体释放的微小卵后发育。在这里,我们描述了寄生虫的生命阶段,诊断,发病机理,神经囊虫病的症状以及预防和控制措施。强调需要验证流行地区的诊断工具,治疗方法和疫苗接种,面临着应对缺乏资源的最脆弱人群的挑战。如果人们了解传播途径,避免进食未煮熟的肉或未充分煮熟的肉,并具有足够的卫生习惯,这是三种人畜共患Ta虫的生命周期种可能被打断。此外,我们描述了由寄生虫引起的免疫应答和免疫调节的不断发展的领域,这可能为诊断,治疗,控制虫/囊尾rc病以及鉴定可帮助治疗的寄生虫衍生免疫调节剂提供必要的工具。世界范围内出现的炎性疾病。

更新日期:2020-12-14
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