Impaired social cue perception such as emotional recognition is a prominent feature in patients with schizophrenia, adversely affecting psychosocial outcomes and worsening clinical manifestations of the disease. However, few structural neuroimaging studies have investigated both facial emotion recognition and emotion intensity recognition in schizophrenia. Ninety patients with schizophrenia spectrum psychosis and fifty healthy controls underwent structural magnetic resonance imaging. The gray matter volumes of emotion recognition areas such as the bilateral caudal anterior cingulate cortex, rostral anterior cingulate cortex, fusiform gyrus, insula, amygdala, and hippocampus, were compared between patients and controls. Emotional recognition levels and symptom severities were examined. Group analysis showed that the gray matter volumes of the patients were significantly smaller in left hippocampus and fusiform gyrus compared with healthy controls. A correlation analysis revealed that larger left fusiform gyrus volume was associated with better facial emotion recognition and emotional intensity recognition in patients with schizophrenia spectrum psychosis. Additionally, left fusiform gyrus volumes showed a significant negative correlation with the negative symptom scores at baseline. These findings suggest that gray matter abnormalities in the left fusiform gyrus are associated with impaired social emotion recognition and severity of negative symptoms at baseline in patients with schizophrenia spectrum psychosis.

中文翻译：

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精神分裂症谱系精神病患者面部表情识别和情绪强度识别受损与梭状回体积减少相关

社会线索感知（如情绪识别）受损是精神分裂症患者的一个突出特征，会对社会心理结果产生不利影响，并使疾病的临床表现恶化。然而，很少有结构神经影像学研究调查了精神分裂症中的面部情绪识别和情绪强度识别。90 名精神分裂症谱系精神病患者和 50 名健康对照者接受了结构磁共振成像。比较患者和对照组之间情绪识别区域的灰质体积，如双侧尾前扣带回皮层、嘴前扣带回皮层、梭状回、岛叶、杏仁核和海马体。检查了情绪识别水平和症状严重程度。分组分析显示，与健康对照组相比，患者左侧海马和梭状回的灰质体积明显较小。相关分析表明，较大的左侧梭状回体积与精神分裂症谱系精神病患者更好的面部情绪识别和情绪强度识别相关。此外，左侧梭状回体积与基线时的阴性症状评分呈显着负相关。这些发现表明，左侧梭状回的灰质异常与精神分裂症谱系精神病患者基线时社会情绪识别能力受损和阴性症状严重程度有关。相关分析表明，较大的左侧梭状回体积与精神分裂症谱系精神病患者更好的面部情绪识别和情绪强度识别相关。此外，左侧梭状回体积与基线时的阴性症状评分呈显着负相关。这些发现表明，左侧梭状回的灰质异常与精神分裂症谱系精神病患者基线时社会情绪识别能力受损和阴性症状严重程度有关。相关分析表明，较大的左侧梭状回体积与精神分裂症谱系精神病患者更好的面部情绪识别和情绪强度识别相关。此外，左侧梭状回体积与基线时的阴性症状评分呈显着负相关。这些发现表明，左侧梭状回的灰质异常与精神分裂症谱系精神病患者基线时社会情绪识别能力受损和阴性症状严重程度有关。左梭状回体积与基线时的阴性症状评分呈显着负相关。这些发现表明，左侧梭状回的灰质异常与精神分裂症谱系精神病患者基线时社会情绪识别能力受损和阴性症状严重程度有关。左梭状回体积与基线时的阴性症状评分呈显着负相关。这些发现表明，左侧梭状回的灰质异常与精神分裂症谱系精神病患者基线时社会情绪识别能力受损和阴性症状严重程度有关。