Abstract Asthma is one of the most common chronic diseases among children and has affected about 300 million individuals worldwide according to the report of the world health organization. Herein, we present the first electrochemiluminescence (ECL) report for the determination of an important antiasthmatic drug (Bambuterol). It was found that bambuterol can act as an efficient coreactant for Ru(bpy)32+ ECL via oxidation-reduction pathway. The electrogenerated reducing species from bambuterol and Ru(bpy)32+ could react together at the surface of gold electrode to generate an intense ECL signal Based on this new finding, the first ECL study was proposed and optimized for the rapid, highly sensitive, and selective screening of bambuterol in its pure form with a wide linearity of 10.0 nM - 2.0 μM and an ultra-low detection limit of 1.48 nM. The developed system was applied for assaying bambuterol in pharmaceutical preparations. Furthermore, the developed system was also utilized to determine the content uniformity of bambuterol in low dose tablets.

中文翻译：

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三（2,2'-联吡啶）钌（II）的放大阳极电化学发光用于超灵敏检测班布特罗：在含量均匀度测试中的应用

摘要 哮喘是儿童中最常见的慢性病之一，根据世界卫生组织的报告，全世界约有 3 亿人受到影响。在此，我们提出了第一份电化学发光 (ECL) 报告，用于测定一种重要的抗哮喘药物 (班布特罗)。发现班布特罗可以通过氧化还原途径作为 Ru(bpy)32+ ECL 的有效共反应物。来自班布特罗和 Ru(bpy)32+ 的电还原物质可以在金电极表面共同反应以产生强烈的 ECL 信号基于这一新发现，首次提出并优化了 ECL 研究，以实现快速、高灵敏度和选择性筛选纯形式的班布特罗，具有 10.0 nM - 2.0 μM 的宽线性和 1.48 nM 的超低检测限。开发的系统用于检测药物制剂中的班布特罗。此外，开发的系统还用于确定低剂量片剂中班布特罗的含量均匀度。