Bone defects caused by trauma and surgery are common clinical problems encountered by orthopedic surgeons. Thus, a hard-textured, natural-like biomaterial that enables encapsulated cells to obtain the much-needed biophysical stimulation and produce functional bone tissue is needed. Incorporating nanomaterials into cell-laden hydrogels is a straightforward tactic for producing tissue engineering structures that integrate perfectly with the body and for tailoring the material characteristics of hydrogels without hindering nutrient exchange with the surroundings. In this review, recent developments in inorganic nanocomposite hydrogels for bone tissue engineering that are of vital importance but have not yet been comprehensively reviewed are summarized.

外伤和手术引起的骨缺损是骨科医生遇到的常见临床问题。因此，需要一种质地坚硬、类似天然的生物材料，使封装的细胞能够获得急需的生物物理刺激并产生功能性骨组织。将纳米材料融入充满细胞的水凝胶中是一种直接的策略，可生产与身体完美融合的组织工程结构，并在不妨碍与周围环境的营养物质交换的情况下定制水凝胶的材料特性。在这篇综述中，总结了用于骨组织工程的无机纳米复合水凝胶的最新进展，这些进展至关重要但尚未得到全面综述。