Combinations of ionic liquids (ILs) with antimicrobial compounds have been shown to produce synergistic activities in model liposomes. In this study, imidazolium chloride-based ILs with alkyl tail length variations are combined with commercially available, small-molecule antimicrobials to examine the potential for combinatorial and synergistic antimicrobial effects on P. aeruginosa, E. coli, S. aureus, and S. cerevisiae. The effects of these treatments in a human cell culture model indicate the cytotoxic limits of ILs paired with antimicrobials. The analysis of these ILs demonstrates that the length of the alkyl chain on the IL molecule is proportional to both antimicrobial activity and cytotoxicity. Moreover, the ILs which exhibit synergy with small-molecule antibiotics appear to be acting in a membrane permeabilizing manner. Collectively, results from these experiments demonstrate an increase in antimicrobial efficacy with specific IL + antimicrobial combinations on microbial cultures while maintaining low cytotoxicity in a mammalian cell culture model.

离子液体 (IL) 与抗菌化合物的组合已被证明可以在模型脂质体中产生协同活性。在这项研究中，将烷基尾长度不同的基于氯化咪唑的离子液体与市售小分子抗菌剂相结合，以研究对铜绿假单胞菌、大肠杆菌、金黄色葡萄球菌和金黄色葡萄球菌的组合和协同抗菌作用的潜力。酿酒酵母。这些治疗方法在人类细胞培养模型中的效果表明了 IL 与抗菌药物配对的细胞毒性极限。对这些 IL 的分析表明，IL 分子上烷基链的长度与抗菌活性和细胞毒性成正比。此外，与小分子抗生素表现出协同作用的IL似乎以膜透化方式发挥作用。总的来说，这些实验的结果表明，特定的 IL + 抗菌组合可提高微生物培养物的抗菌功效，同时在哺乳动物细胞培养模型中保持低细胞毒性。