Two neutral iridium complexes with L-alanine as ancillary ligands, (thp)₂Ir(L-alanine) (Ir1) (thp = 2-(thiophen-2-yl)pyridine) and (btp)₂Ir(L-alanine) (Ir2) (btp = 2-(benzo[b]thiophen-2-yl)pyridine) were synthesized and investigated. The solid-state structures of the developed Ir1 and Ir2 were authenticated by single X-ray diffraction. Ir(III) complexes Ir1 and Ir2 exhibit intense yellow and red emission respectively with high quantum efficiencies (Φ_em = 0.88 for Ir1, Φ_em = 0.29 for Ir2) in oxygen-free acetonitrile solution at room temperature. Theoretical calculations were carried out to provide a further study of the orbital distributions and electronic states of the two complexes. The two complexes displayed significant reversible phosphorescence quenching upon binding to Cu²⁺ ion and the binding stoichiometry was approximately 1:1. ¹H NMR titration experiments indicated that coordination of Cu²⁺ to the nitrogen atoms of the L-alanine ligands of the complexes induce the significant variations in optical signals. This work showed that new phosphorescent probes based on iridium complexes could be realized by introducing simple amino acid ancillary ligands.

两个具有L-丙氨酸作为辅助配体的中性铱配合物，（thp）₂ Ir（L-丙氨酸）（Ir1）（thp = 2-（噻吩-2-基）吡啶）和（btp）₂ Ir（L-丙氨酸）合成并研究了（Ir2）（btp = 2-（苯并[ b ]噻吩-2-基）吡啶）。通过单次X射线衍射验证了开发的Ir1和Ir2的固态结构。铱（III）配合物IR1和亮点Ir2分别表现出强烈的黄色和红色发射具有高量子效率（Φ _EM = 0.88为IR1，Φ _EM = 0.29为亮点Ir2）在室温下的无氧乙腈溶液中。进行了理论计算，以进一步研究两个配合物的轨道分布和电子状态。两种复合物在与Cu ²⁺离子结合后显示出显着的可逆磷光猝灭，结合化学计量比约为1：1。¹ H NMR滴定实验表明，Cu ²⁺与配合物的L-丙氨酸配体的氮原子配位引起光信号的显着变化。这项工作表明，通过引入简单的氨基酸辅助配体可以实现基于铱配合物的新型磷光探针。