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Nanotechnology in the diagnosis and treatment of stroke
Drug Discovery Today ( IF 6.5 ) Pub Date : 2020-11-23 , DOI: 10.1016/j.drudis.2020.11.018
Deepaneeta Sarmah 1 , Mainak Banerjee 2 , Aishika Datta 1 , Kiran Kalia 1 , Shanta Dhar 3 , Dileep R Yavagal 4 , Pallab Bhattacharya 1
Affiliation  

Increasing developments in the field of nanotechnology have ignited its use in stroke diagnosis and treatment. The benefits of structural modification, ease of synthesis, and biocompatibility support the use of nanomaterials in the clinic. The pathophysiology of stroke is complex, involving different brain regions; hence, therapeutic agents are required to be delivered to specific regions. Nanoparticles (NPs) can be engineered to help improve the delivery and release of therapeutic agents in a localized manner, especially in the penumbra. This contributes not only to therapy, but also to neurosurgery and neuroimaging. Nanomaterials also offer high efficacy with few adverse effects. In this review, we provide a concise summary of the caveats associated with nanotechnology with respect to stroke therapy and diagnosis.



中文翻译:

纳米技术在中风诊断和治疗中的应用

纳米技术领域的不断发展激发了其在中风诊断和治疗中的应用。结构修饰、易于合成和生物相容性的优点支持纳米材料在临床中的使用。中风的病理生理学很复杂,涉及不同的大脑区域;因此,需要将治疗剂递送到特定区域。纳米颗粒 (NP) 可以被设计为帮助改善治疗药物的局部递送和释放,尤其是在半影区域。这不仅有助于治疗,也有助于神经外科和神经影像学。纳米材料还具有高效能且副作用少的特点。在这篇综述中,我们简要总结了纳米技术在中风治疗和诊断方面的注意事项。

更新日期:2020-11-23
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