Benign prostatic hyperplasia (BPH) is a disorder related to hormone imbalance, local angiogenesis, and prostate growth, which can be treated surgically (orchiectomy) or medically (most commonly with finasteride). However, finasteride therapy is not completely established in dogs regarding local action and posology. This study aimed to evaluate the effect of different doses of finasteride and orchiectomy on hormonal profile, prostate apoptosis, blood flow, and biometry in dogs with BPH. Dogs were assigned to the following groups: untreated, 0.1 mg, 0.2 mg, and 0.5 mg/kg/d of finasteride and orchiectomy. All dogs were assessed monthly: day 0 (before treatment), day 30, and day 60 and subjected to prostate B-mode and Doppler ultrasonography and hormonal analysis (testosterone and dihydrotestosterone). After 60 d, prostatic biopsy was performed for histology and immunohistochemical evaluation for apoptosis (caspase-3). On day 60, percentage reduction of prostatic volume was greater in orchiectomized dogs than that in finasteride groups, which, conversely, was greater than untreated dogs. On day 60, 0.2-mg finasteride, 0.5-mg finasteride, and orchiectomy groups had higher prostatic blood flow than 0.1-mg finasteride and untreated groups. In addition, both 0.5-mg finasteride and orchiectomy groups had an increase in prostate artery resistance. Orchiectomy significantly decreased androgen concentrations at 30 d onward, differing from the remaining groups. The orchiectomy group had lower caspase-3 immunostaining, however, not different from untreated and 0.5-mg finasteride. In conclusion, 0.5 mg/kg finasteride promoted more effective prostate apoptosis and hemodynamic effects among medical treatments, whereas orchiectomy caused prostate atrophy and sharp endocrine changes in dogs with BPH.

良性前列腺增生 (BPH) 是一种与激素失衡、局部血管生成和前列腺生长有关的疾病，可以通过手术（睾丸切除术）或药物治疗（最常见的是非那雄胺）。然而，关于局部作用和剂量学，非那雄胺治疗在狗中尚未完全确立。本研究旨在评估不同剂量的非那雄胺和睾丸切除术对 BPH 犬的激素谱、前列腺细胞凋亡、血流和生物测定的影响。狗被分配到以下组：未治疗、0.1 mg、0.2 mg 和 0.5 mg/kg/d 的非那雄胺和睾丸切除术。每月对所有狗进行评估：第 0 天（治疗前）、第 30 天和第 60 天，并接受前列腺 B 模式和多普勒超声检查和激素分析（睾酮和二氢睾酮）。60 d 后，进行前列腺活检以进行组织学和免疫组织化学评估细胞凋亡（caspase-3）。在第 60 天，切除睾丸的狗的前列腺体积减少百分比大于非那雄胺组，相反，后者大于未治疗的狗。在第 60 天，0.2-mg 非那雄胺、0.5-mg 非那雄胺和睾丸切除术组的前列腺血流量高于 0.1-mg 非那雄胺和未治疗组。此外，0.5 mg 非那雄胺组和睾丸切除术组的前列腺动脉阻力均有所增加。睾丸切除术在 30 天后显着降低了雄激素浓度，这与其余组不同。睾丸切除术组的 caspase-3 免疫染色较低，但与未治疗组和 0.5 mg 非那雄胺没有区别。总之，0。