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Ubiquitin Tunes Hedgehog in Matters of the Heart
Developmental Cell ( IF 10.7 ) Pub Date : 2020-11-23 , DOI: 10.1016/j.devcel.2020.10.017
Sandii Constable , Saikat Mukhopadhyay

Oligogenic inheritance makes the etiology of developmental diseases challenging to determine. In this issue of Developmental Cell, Kong et al., 2020 identify members of a membrane-tethered ubiquitin complex that attenuates Hedgehog signaling strength and genetically interact to regulate digit number, body patterning, and cardiac development.



中文翻译:

泛素在心脏问题上调节刺猬

寡聚遗传使发展性疾病的病因学难以确定。在《发展细胞》一期中,Kong等人,2020年确定了膜连接的泛素复合物的成员,该复合物减弱了刺猬的信号强度,并通过基因相互作用来调节数字,身体构图和心脏发育。

更新日期:2020-11-23
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