Oligogenic inheritance makes the etiology of developmental diseases challenging to determine. In this issue of Developmental Cell, Kong et al., 2020 identify members of a membrane-tethered ubiquitin complex that attenuates Hedgehog signaling strength and genetically interact to regulate digit number, body patterning, and cardiac development.

中文翻译：

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泛素在心脏问题上调节刺猬

寡聚遗传使发展性疾病的病因学难以确定。在《发展细胞》一期中，Kong等人，2020年确定了膜连接的泛素复合物的成员，该复合物减弱了刺猬的信号强度，并通过基因相互作用来调节数字，身体构图和心脏发育。