A porous aromatic framework (PAF) is shown to be a viable sorbent for the adsorption of phenols. To overcome the difficulty of quick adsorption and enrichment by phenols from the matrix, a sorbent material consisting of porous aromatic framework magnetic nanoparticles (PAF MNPs) with a core–shell structure was fabricated by an in situ growth method. The PAF MNP sorbent was characterized by transmission electron microscopy, Fourier transform infrared spectroscopy and other techniques. The factors affecting enrichment performance including the amount of PAF-6 MNPs, sample pH, extraction time and elution conditions were optimized. Under the optimal conditions, a method utilizing high-performance liquid chromatography with an ultraviolet detector (HPLC-UV) was developed to quantify phenols in urine. The method showed good linearity (r ≥ 0.998), good precision (RSD ≤ 9.9%, n = 6) and a low limit of detection (1.0–2.0 ng/mL, S/N = 3), with recoveries performed in urine matrix ranging from 76.7% to 113.2%. The method is simple, time-saving and sensitive. Moreover, compared with traditional mass spectrometry detection methods, this method has advantages in terms of low cost and repeatability.

多孔芳族骨架（PAF）被证明是吸附酚的可行吸附剂。为了克服酚从基质快速吸附和富集的困难，通过原位生长方法制备了一种由具有核-壳结构的多孔芳族骨架磁性纳米颗粒（PAF MNP）组成的吸附材料。通过透射电子显微镜，傅立叶变换红外光谱和其他技术对PAF MNP吸附剂进行了表征。优化了影响富集性能的因素，包括PAF-6 MNP的量，样品pH，萃取时间和洗脱条件。在最佳条件下，开发了一种利用高效液相色谱仪和紫外检测器（HPLC-UV）定量尿液中苯酚的方法。该方法显示出良好的线性（r≥0.998），n  = 6）和低检测限（1.0–2.0 ng / mL，S / N  = 3），尿基质中的回收率范围为76.7％至113.2％。该方法简单，省时，灵敏。此外，与传统的质谱检测方法相比，该方法在成本和可重复性方面均具有优势。