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Epidemiology and antibiotic resistance profile of bacterial meningitis in Morocco from 2015 to 2018.
Acta Microbiologica et Immunologica Hungarica ( IF 1.3 ) Pub Date : 2020-11-21 , DOI: 10.1556/030.2020.01222
Youssef Ikken 1, 2 , Réda Charof 2 , Amina Benaouda 3 , Farida Hilali 1 , Sanae Akkaoui 4 , Mostafa Elouennass 5 , Yassine Sekhsokh 1
Affiliation  

Over a 4-year study period from 2015 to 2018, altogether 183 isolates of bacterial meningitis were collected from 12 hospitals covering the entire Moroccan territory. Neisseria meningitidis represented 58.5%, Streptococcus pneumoniae 35.5%, and Haemophilus influenzae type b 6%. H. influenzae type b mainly affected 5-year-olds and unvaccinated adults. N. meningitidis serogroup B represented 90.7% followed by serogroup W135 with 6.5%. Decreased susceptibility to penicillin G (DSPG) for all isolates accounted for 15.7%, with 11.6% being resistant to penicillin G (PG) and 4.1% decreased susceptibility. Cumulative results of all strains showed 2.7% decreased susceptibility to amoxicillin and 3.3% resistant, 2.2% of isolates were resistant to third-generation cephalosporin and 2.2% were decreased susceptible, 5.5% were resistant to chloramphenicol and 2.7% were resistant to rifampin. The frequency of DSPG observed in our study is more common in S. pneumoniae than in N. meningitidis (P < 0.05). These isolates have been found to be highly susceptible to antibiotics used for treatment and prophylaxis chemotherapy and the observed resistance remains rare. The impact of introduction of conjugate vaccines against H. influenzae type b and S. pneumoniae (PCVs) is an advantage in reducing meningitis cases due to these two species.

中文翻译:

2015 年至 2018 年摩洛哥细菌性脑膜炎的流行病学和抗生素耐药性概况。

在 2015 年至 2018 年的 4 年研究期间,从覆盖整个摩洛哥领土的 12 家医院共收集了 183 株细菌性脑膜炎菌株。脑膜炎奈瑟菌占 58.5%,肺炎链球菌占 35.5%,b 型流感嗜血杆菌占 6%。B 型流感嗜血杆菌主要影响 5 岁儿童和未接种疫苗的成年人。脑膜炎奈瑟菌血清群 B 占 90.7%,其次是血清群 W135,占 6.5%。所有分离株对青霉素 G (DSPG) 敏感性降低的占 15.7%,其中 11.6% 对青霉素 G (PG) 耐药,4.1% 敏感性降低。所有菌株的累积结果显示,对阿莫西林的敏感性降低 2.7%,耐药性降低 3.3%,2.2% 的分离株对第三代头孢菌素耐药,2.2% 的敏感性降低,5.5% 对氯霉素和 2.3 代头孢菌素耐药。7% 对利福平耐药。在我们的研究中观察到的 DPG 频率在肺炎链球菌中比在脑膜炎奈瑟菌中更常见(P < 0.05)。已发现这些分离株对用于治疗和预防性化疗的抗生素高度敏感,观察到的耐药性仍然很少见。引入针对 b 型流感嗜血杆菌和肺炎链球菌 (PCV) 的结合疫苗的影响是减少这两种物种引起的脑膜炎病例的优势。
更新日期:2020-11-24
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