According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030. So the anticancer drug research and development is taking place in the direction where the new entities are developed which are low in toxicity and are with improved activity. Benzoxazole and its derivative represent a very important class of heterocyclic compounds, which have a diverse therapeutic area. Recently, many active compounds synthesized are very effective; natural products isolated with benzoxazole moiety have also shown to be potent towards cancer. In the last few years, many research groups have designed and developed many novel compounds with benzoxazole as their backbone and checked their anticancer activity. In the review article, the recent developments (mostly after 2015) made in the direction of design and synthesis of new scaffolds with very potent anticancer activity are briefly described. The effect of various heterocycles attached to the benzoxazole and their effect on the anticancer activity are thoroughly studied and recorded in the review. These compiled data in the article will surely update the scientific community with the recent development in this area and will provide direction for further research in this area.

中文翻译：

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苯并恶唑衍生物的抗癌活性（2015年起）：综述

根据世界卫生组织最近发布的报告，到2030年，世界癌症病例数将增加到2200万。因此，抗癌药的研究和开发正朝着新的实体发展的方向发展，而这些新实体的数量很少。具有毒性，并具有改善的活性。苯并恶唑及其衍生物代表非常重要的一类杂环化合物，其治疗领域广泛。最近，许多合成的活性化合物非常有效。用苯并恶唑部分分离的天然产物也已显示出对癌症有效。在最近几年中，许多研究小组设计并开发了许多以苯并恶唑为骨架的新型化合物，并检查了它们的抗癌活性。在评论文章中，简要介绍了在新的具有非常强的抗癌活性的支架的设计和合成方向上的最新进展（大部分在2015年之后）。本综述全面研究并记录了各种与苯并恶唑连接的杂环的作用及其对抗癌活性的影响。本文中的这些编译数据必将为科学界提供该领域的最新进展，并为该领域的进一步研究提供指导。