ABSTRACT

C-H activation is a prominent tool in organic synthesis. The potential application of C-H activation in the diversification of heterocycles has attracted widespread industrial interest. Reactions involving alkylation, alkenylation, and alkynylation have an edge in modern organic synthesis and are widely employed to synthesize vital molecules. Among different metal catalysts used in C-H activation of heterocycles, group 9 (Co, Rh, Ir) metal complexes particularly MCp* have emerged as powerful catalysts. The current review is focused on the recent developments in the Group 9 transition metal (Rh, Ir, Co) catalyzed alkylation, alkenylation, and alkynylation of the heterocycles via C-H bond activation.

摘要

CH活化是有机合成中的重要工具。CH活化在杂环多样化中的潜在应用引起了广泛的工业兴趣。涉及烷基化、烯基化和炔基化的反应在现代有机合成中具有优势，并被广泛用于合成重要分子。在用于 CH 活化杂环的不同金属催化剂中，第 9 族（Co、Rh、Ir）金属配合物，特别是 MCp* 已成为强大的催化剂。目前的综述集中在第 9 族过渡金属（Rh、Ir、Co）催化的杂环通过CH 键活化的烷基化、烯基化和炔基化的最新进展。