Multiomic analysis identifies natural intrapatient temporal variability and changes in response to systemic corticosteroid therapy in chronic rhinosinusitis,Immunity, Inflammation and Disease

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Multiomic analysis identifies natural intrapatient temporal variability and changes in response to systemic corticosteroid therapy in chronic rhinosinusitis
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-11-21 , DOI: 10.1002/iid3.349
Michael Hoggard ₁ , Bincy Jacob _{1,

2} , David Wheeler ₃ , Melissa Zoing ₄ , Kevin Chang ₅ , Kristi Biswas ₄ , Martin Middleditch _{1,

2} , Richard G Douglas ₄ , Michael W Taylor _{1,

6}

Affiliation

The pathophysiology and temporal dynamics of affected tissues in chronic rhinosinusitis (CRS) remain poorly understood. Here, we present a multiomics‐based time‐series assessment of nasal polyp biopsies from three patients with CRS, assessing natural variability over time and local response to systemic corticosteroid therapy.

中文翻译：

多组学分析确定慢性鼻窦炎患者对全身皮质类固醇治疗的自然时间变异性和变化

慢性鼻窦炎 (CRS) 中受影响组织的病理生理学和时间动态仍然知之甚少。在这里，我们对来自三名 CRS 患者的鼻息肉活检进行了基于多组学的时间序列评估，评估了随着时间的推移的自然变异性和对全身皮质类固醇治疗的局部反应。

更新日期：2020-11-21

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