Loperamide exerts a direct bactericidal effect against M. tuberculosis, M. bovis, M. terrae, and M. smegmatis .,Letters in Applied Microbiology

当前位置： X-MOL 学术 › Lett. Appl. Microbiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Loperamide exerts a direct bactericidal effect against M. tuberculosis, M. bovis, M. terrae, and M. smegmatis .
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-12-01 , DOI: 10.1111/lam.13432
O.M. Barrientos ₁ , E. Juárez ₁ , Y. Gonzalez ₁ , D.A. Castro‐Villeda ₁ , M. Torres ₂ , S. Guzmán‐Beltrán ₁

Affiliation

Tuberculosis (TB) is caused by M. tuberculosis. TB is highly prevalent, characterized by the constant occurrence of drug-resistant cases, and confounded by the incidence of respiratory disease caused by Non-tuberculous mycobacteria (NTB). Expanding the spectrum of drugs for the treatment of TB is indispensable. Loperamide, an anti-diarrhea drug, enhances immune-driven antimycobacterial activity, and we aimed to evaluate its bactericidal activity against M. tuberculosis, M. bovis BCG, M. terrae, and M. smegmatis. Loperamide exhibited an inhibitory effect against all mycobacterial species tested, with MICs of 100 and 150 μg ml-1 . Thus, loperamide is a mycobactericidal drug with potential as adjunctive therapy for TB and NTB infections.

中文翻译：

洛哌丁胺对结核分枝杆菌、牛分枝杆菌、土分枝杆菌和耻垢分枝杆菌具有直接杀菌作用。

结核病 (TB) 是由结核分枝杆菌引起的。结核病高度流行，其特点是耐药病例不断发生，并被非结核分枝杆菌 (NTB) 引起的呼吸道疾病的发病率所混淆。扩大治疗结核病的药物谱是必不可少的。洛哌丁胺是一种抗腹泻药物，可增强免疫驱动的抗分枝杆菌活性，我们旨在评估其对结核分枝杆菌、牛分枝杆菌 BCG、土分枝杆菌和耻垢分枝杆菌的杀菌活性。洛哌丁胺对所有测试的分枝杆菌种均表现出抑制作用，MIC 为 100 和 150 μg ml-1。因此，洛哌丁胺是一种分枝杆菌药物，具有作为 TB 和 NTB 感染的辅助治疗潜力。

更新日期：2020-12-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11