Off cone bipolar cells of the mammalian retina connect to cone photoreceptor synaptic terminals via non‐invaginating flat contacts at a considerable distance from the only established neurotransmitter release site so far, the synaptic ribbon. Diffusion from the ribbon synaptic active zone is considered the most likely mechanism for the neurotransmitter glutamate to reach postsynaptic receptors on the dendritic tips of Off cone bipolar cells. We used a mutant mouse with functionally impaired photoreceptor ribbon synapses to investigate the importance of intact ribbon synaptic active zones for signal transmission at Off cone bipolar cell contacts.

中文翻译：

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锥光感受器带突触中功能性巴松管的缺失影响了小鼠视网膜离锥双极细胞接触处的信号传输

哺乳动物视网膜的离锥双极细胞通过与迄今为止唯一建立的神经递质释放位点突触带相距相当远的非内陷平面接触连接到锥光感受器突触末端。从带状突触活动区的扩散被认为是神经递质谷氨酸最可能到达离锥双极细胞树突尖端上的突触后受体的机制。我们使用功能受损的光感受器带状突触的突变小鼠来研究完整的带状突触活动区对于在离锥双极细胞接触处进行信号传输的重要性。