Development of an efficient, one‐pot, multicomponent protocol for synthesis of 8‐hydroxy‐4‐phenyl‐1,2‐dihydroquinoline derivatives,Journal of Heterocyclic Chemistry

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Development of an efficient, one‐pot, multicomponent protocol for synthesis of 8‐hydroxy‐4‐phenyl‐1,2‐dihydroquinoline derivatives
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-11-21 , DOI: 10.1002/jhet.4193
Rukhsana Tabassum ₁ , Muhammad Ashfaq ₁ , Hiroyuki Oku ₂

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A one‐pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8‐hydroxy‐4‐phenyl‐1,2‐dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol run smoothly to give variety of quinoline derivatives in 55% to 98% yield from inexpensive reagents and catalyst in mild reaction conditions. Various spectroscopic techniques like FTIR, ¹H NMR and ¹³C NMR, MALDI‐TOF‐MS, and EI‐MS were used to study and confirm their structure.

中文翻译：

开发一种高效、一锅、多组分合成 8-羟基-4-苯基-1,2-二氢喹啉衍生物的方案

我们开发了一种快速高效的一锅多组分反应，以 30 mol% 乙酸铵的乙醇溶液为溶剂，合成一系列新型官能化 8-羟基-4-苯基-1,2-二氢喹啉衍生物。这种经济的方案运行平稳，在温和的反应条件下，用廉价的试剂和催化剂以 55% 至 98% 的产率产生各种喹啉衍生物。使用FTIR、¹ H NMR 和¹³ C NMR、MALDI-TOF-MS 和 EI-MS 等各种光谱技术来研究和确认其结构。

更新日期：2020-11-21

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